The San Francisco 49ers seemed to navigate a deluge of injuries last season with a little dental floss and a whole lotta Christian McCaffrey. CMC's RB1 season averaging 24.3 fantasy points per game make things easier. But can some new faces and some returning to health help the 49ers reach greater heights? Ian Hartitz and Dwain McFarland bring you everything you need to know about the 49ers for fantasy football with their 2026 fantasy football cheat sheet, highlighting their fantasy football rankings and more.

San Francisco 49ers 2026 Fantasy Football Cheat Sheet

• 2025 Record / Rank in PPG: 12-5 / 25.7 (10)
• 2026 Proj TDs per game: 2.8 (rank: 5)
• Head Coach: Kyle Shanahan
• Offensive Playcaller: Shanahan (OC Klay Kubiak)
• Projected Plays Per Game: 60 (rank: 23)
• Projected Dropback Rate: 57.3% (rank: 26)
• Matthew Freedman’s Projected Win Total: 9.8
• Offensive Line Grades: B
• Key Departures: Jauan Jennings, Brian Robinson
• Key Additions: Mike Evans, Christian Kirk, De'Zhaun Stribling, Kaelon Black

49ers Fantasy Football Rankings and Depth Chart

QB: Brock Purdy (QB9)

RB: Christian McCaffrey (RB3) | Kaelon Black (RB55) | Jordan James (RB65)

WR: Mike Evans (WR22) | Ricky Pearsall (WR44) | Christian Kirk (WR60) | De’Zhaun Stribling (WR94)

TE: George Kittle (TE17) | Jake Tonges (TE35)

2026 Fantasy Football Overview for the San Francisco 49ers

Brock Purdy ranks first in the Super Bowl era in career yards per attempt and passer rating. He's the QB6 in fantasy points per game since 2023. The system and environment have helped, but in recent years the team's top playmakers have missed plenty of time. Purdy is a screaming buy at his borderline QB1 price tag in fantasy land.

Christian McCaffrey has finished as a top-3 fantasy RB in five of the last eight seasons. The concern is that the 30-year-old talent is coming off an insane 450 touches, and HC Kyle Shanahan has stated this offseason that CMC "needs some help." That said: Good luck ranking five RBs ahead of McCaffrey. Either way, third-round rookie Kaelon Black suddenly profiles as one of fantasy's better handcuff options after Brian Robinson departed for Atlanta during free agency.

Mike Evans' injury-riddled 2025 featured career-worst numbers in pretty much every statistic. The glass-half-full bounceback scenario for the soon-to-be 33-year-old revolves around marketable upgrades in the QB, scheme and volume departments. Failure for Evans to function as his typical alpha self would put more on the plate of third-year talent Ricky Pearsall, veteran Christian Kirk, and No. 33 overall pick De’Zhaun Stribling. No parties here are without risk; just realize Purdy and Shanahan have consistently produced one of the league's most efficient aerial attacks together. 

George Kittle apparently has a chance to be ready for Week 1 despite suffering a torn Achilles last January. While it's certainly scary to bet on a 32-year-old tight end coming back from what's usually a devastating injury, the TE2 price tag does make Kittle a reasonable late-round dart. Credit to Jake Tonges for working as the TE9 in total PPR points in Weeks 1-6 with Kittle sidelined last season.

SF 49ers Utilization Notes 

Mike Evans will be 33 and is coming off his worst fantasy season ever, averaging 10.6 fantasy points (WR41). He dealt with significant injuries last year, delivering 1.62 yards per route. Still, he was earning opportunities at a high rate with a 26% targets per route, and the 49ers decided to bet on the aging WR with a three-year $42.5M contract with $16.3M in guarantees. With San Francisco, Evans will play in a potential top-5 offense with an exceptional schemer in Kyle Shanahan. Evans projects as a mid-range WR2 with WR1 upside if healthy.

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